BILATERAL ISOLATED NASAL CLEFT MANAGEMENT: A FACILE SOLUTION OR A TREATMENT CONUNDRUM?

Alar defects are usually secondary to trauma or nasal tumour excision.Congenital alar defects are rare of which isolated bilateral nasal clefts are extremely sparse.Reconstruction of these bilateral nasal clefts poses additional challenge due to lack of NAIL/DOMES equivalent structural analogue on the opposite side to weigh against.Myriad of strate

Purpose: TRPM2 is a Ca2+-permeable channel that is activated by H2O2.TRPM2-mediated Ca2+ signaling has been implicated in the aggravation of inflammatory diseases.Therefore, the development of TRPM2 inhibitors to prevent the aggravation of these diseases is expected.We recently reported that some Tyrphostin AG-related Resveratrol compounds inhibite